General Information

  • ID:  hor001342
  • Uniprot ID:  E9HK97
  • Protein name:  FIRFamide1
  • Gene name:  NA
  • Organism:  Daphnia pulex (Water flea)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Daphnia (genus), Daphniidae (family), Anomopoda (infraorder), Cladocera (suborder), Diplostraca (order), Phyllopoda (subclass), Branchiopoda (class), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SALNKNFIRF
  • Length:  10(105-114)
  • Propeptide:  MNGLRFLMLILGLMMIVGQVRPDDETSEEDVDDENFLSGSNAAAAAGSSDSAEEDDDNNNNKGGIELYLSAMKDLYRQSKRHEAEPLVSSRSGASAPIAALYRRSALNKNFIRFGRSGGGVMKTDVSRQMQPIRLMGLNESDSGKDEERSFHPARPSRSLRSNFIRFGRSFFPTSNRWGETVRRSARRTPSAGRQMMSLVDLPASSSSSSRR
  • Signal peptide:  MNGLRFLMLILGLMMIVGQVRP
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E9HK97-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001342_AF2.pdbhor001342_ESM.pdb

Physical Information

Mass: 137012 Formula: C56H88N16O14
Absent amino acids: CDEGHMPQTVWY Common amino acids: FN
pI: 11.65 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: -5 Boman Index: -1954
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 88
Instability Index: 1765 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21830762
  • Title:  Genomics, Transcriptomics, and Peptidomics of Daphnia Pulex Neuropeptides and Protein Hormones